Joel S. Freundlich: search on Z-Library

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1

Radiosynthesis and Biodistribution of 18 F-Linezolid in Mycobacterium tuberculosis -Infected Mice Using Positron Emission Tomography

Mota, Filipa, Jadhav, Ravindra, Ruiz-Bedoya, Camilo A., Ordonez, Alvaro A., Klunk, Mariah H., Freundlich, Joel S., Jain, Sanjay K.

Journal:

ACS Infectious Diseases

Year:

2020

File:

PDF, 1.29 MB

2020

2

The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro

Lane, Thomas, Anantpadma, Manu, Freundlich, Joel S., Davey, Robert A., Madrid, Peter B., Ekins, Sean

Journal:

Pharmaceutical Research

Year:

2019

Language:

english

File:

PDF, 1.19 MB

english, 2019

3

A Virtual Screen Discovers Novel, Fragment-Sized Inhibitors of Mycobacterium tuberculosis InhA

Perryman, Alexander L., Yu, Weixuan, Wang, Xin, Ekins, Sean, Forli, Stefano, Li, Shao-Gang, Freundlich, Joel S., Tonge, Peter J., Olson, Arthur J.

Journal:

Journal of Chemical Information and Modeling

Year:

2015

Language:

english

File:

PDF, 2.07 MB

english, 2015

4

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

Joel S. Freundlich, Feng Wang, Catherine Vilchèze, Gulcin Gulten, Robert Langley, Guy A. Schiehser, David P. Jacobus, William R. Jacobs Jr., James C. Sacchettini

Journal:

Year:

2009

Language:

english

File:

PDF, 698 KB

english, 2009

5

Transcriptional control of human diploid fibroblast collagen synthesis by γ-interferon

Joel Rosenbloom, George Feldman, Bruce Freundlich, Sergio A. Jimenez

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 775 KB

english, 1984

6

Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015)

Ekins, Sean, Perryman, Alexander Luke, Clark, Alex Michael, Reynolds, Robert C., Freundlich, Joel Stephen

Journal:

Journal of Chemical Information and Modeling

Year:

2016

Language:

english

File:

PDF, 1.55 MB

english, 2016

7

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives

Joel S. Freundlich, John W. Anderson, Dimitri Sarantakis, Hong-Ming Shieh, Min Yu, Juan-Carlos Valderramos, Edinson Lucumi, Mack Kuo, William R. Jacobs Jr., David A. Fidock, Guy A. Schiehser, David P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 268 KB

english, 2005

8

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

Min Yu, T.R. Santha Kumar, Louis J. Nkrumah, Alida Coppi, Silke Retzlaff, Celeste D. Li, Brendan J. Kelly, Pedro A. Moura, Viswanathan Lakshmanan, Joel S. Freundlich, Juan-Carlos Valderramos, Catherin

Journal:

Cell Host & Microbe

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

9

The Abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis

Joel S. Freundlich, Mallikarjun Lalgondar, Jun-Rong Wei, Stephanie Swanson, Erik J. Sorensen, Eric J. Rubin, James C. Sacchettini

Journal:

Year:

2010

Language:

english

File:

PDF, 211 KB

english, 2010

10

Chaperone therapy for mucopolysaccharidosis type IIIC

Pshezhetsky, Alexey V., Pan, Xuefang, Héon-Roberts, Rachel, Li, Shao-Gang, Wu, Harry Y., Taherzadeh, Mahsa, De Aragão, Camila De Britto Pará, Wood, Jill, Ekins, Sean, Boyd, Robert, Freundlich, Joel S.

Journal:

Molecular Genetics and Metabolism

Year:

2018

Language:

english

File:

PDF, 68 KB

english, 2018

11

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Palaninathan, Satheesh K., Mohamedmohaideen, Nilofar N., Orlandini, Elisabetta, Ortore, Gabriella, Nencetti, Susanna, Lapucci, Annalina, Rossello, Armando, Freundlich, Joel S., Sacchettini, James C.,

Journal:

Year:

2009

Language:

english

File:

PDF, 796 KB

english, 2009

12

Radiosynthesis and PET Bioimaging of 76 Br-Bedaquiline in a Murine Model of Tuberculosis

Ordonez, Alvaro A., Carroll, Laurence S., Abhishek, Sudhanshu, Mota, Filipa, Ruiz-Bedoya, Camilo A., Klunk, Mariah H., Singh, Alok K., Freundlich, Joel S., Mease, Ronnie C., Jain, Sanjay K.

Journal:

ACS Infectious Diseases

Year:

2019

File:

PDF, 1.30 MB

2019

13

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

Wilson, Regina, Kumar, Pradeep, Parashar, Vijay, Vilchèze, Catherine, Veyron-Churlet, Romain, Freundlich, Joel S, Barnes, S Whitney, Walker, John R, Szymonifka, Michael J, Marchiano, Emily, Shenai, Sh

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 2.05 MB

english, 2013

14

Enhancing Hit Identification in Mycobacterium tuberculosis Drug Discovery Using Validated Dual-Event Bayesian Models

Ekins, Sean, Reynolds, Robert C., Franzblau, Scott G., Wan, Baojie, Freundlich, Joel S., Bunin, Barry A., Sem, Daniel S.

Journal:

Year:

2013

Language:

english

File:

PDF, 424 KB

english, 2013

15

Combining Cheminformatics Methods and Pathway Analysis to Identify Molecules with Whole-Cell Activity AgainstMycobacterium Tuberculosis

Malabika Sarker, Carolyn Talcott, Peter Madrid, Sidharth Chopra, Barry A. Bunin, Gyanu Lamichhane, Joel S. Freundlich, Sean Ekins

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

16

Predicting Mouse Liver Microsomal Stability with “Pruned” Machine Learning Models and Public Data

Perryman, Alexander L., Stratton, Thomas P., Ekins, Sean, Freundlich, Joel S.

Journal:

Pharmaceutical Research

Year:

2016

Language:

english

File:

PDF, 1.91 MB

english, 2016

17

Machine learning models identify molecules active against the Ebola virus in vitro

Ekins, Sean, Freundlich, Joel S., Clark, Alex M., Anantpadma, Manu, Davey, Robert A., Madrid, Peter

Journal:

Year:

2016

Language:

english

File:

PDF, 3.15 MB

english, 2016

18

A mass threshold for galactic gas discs by spin flips

Dekel, Avishai, Ginzburg, Omri, Jiang, Fangzhou, Freundlich, Jonathan, Lapiner, Sharon, Ceverino, Daniel, Primack, Joel

Journal:

Monthly Notices of the Royal Astronomical Society

Year:

2020

File:

PDF, 4.73 MB

2020

19

Organometallic Complexes of Tantalum That Contain the Triamidoamine Ligand, [(Me3SiNCH2CH2)3N]3-, Including an Ethylidene Complex Formed via a Phosphine-Catalyzed Rearrangement of an Ethylene Complex

Freundlich, Joel S., Schrock, Richard R., Cummins, Christopher C., Davis, William M.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 926 KB

english, 1994

20

Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery

Awasthi, Divya, Freundlich, Joel S.

Journal:

Trends in Microbiology

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

21

Naïve Bayesian Models for Vero Cell Cytotoxicity

Perryman, Alexander L., Patel, Jimmy S., Russo, Riccardo, Singleton, Eric, Connell, Nancy, Ekins, Sean, Freundlich, Joel S.

Journal:

Pharmaceutical Research

Year:

2018

Language:

english

File:

PDF, 1.59 MB

english, 2018

22

Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay

Afanador, Gustavo A., Muench, Stephen P., McPhillie, Martin, Fomovska, Alina, Schön, Arne, Zhou, Ying, Cheng, Gang, Stec, Jozef, Freundlich, Joel S., Shieh, Hong-Ming, Anderson, John W., Jacobus, Davi

Journal:

Year:

2013

Language:

english

File:

PDF, 2.67 MB

english, 2013

23

Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins

Kumar, Pankaj, Chauhan, Varsha, Silva, José Rogério A., Lameira, Jerônimo, d'Andrea, Felipe, Li, Shaogang, Ginell, Stephan L., Freundlich, Joel S., Alves, Cláudio Nahum, Bailey, Scott, Cohen, Keira A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

24

Computational Models for Neglected Diseases: Gaps and Opportunities

Ponder, Elizabeth L., Freundlich, Joel S., Sarker, Malabika, Ekins, Sean

Journal:

Pharmaceutical Research

Year:

2014

Language:

english

File:

PDF, 338 KB

english, 2014

25

Alkyl and Alkylidene Complexes of Tantalum That Contain a Triethylsilyl-Substituted Triamido−Amine Ligand

Freundlich, Joel S., Schrock, Richard R., Davis, William M.

Journal:

Organometallics

Year:

1996

Language:

english

File:

PDF, 262 KB

english, 1996

26

Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights

Li, Shao-Gang, Vilchèze, Catherine, Chakraborty, Sumit, Wang, Xin, Kim, Hiyun, Anisetti, Monica, Ekins, Sean, Rhee, Kyu Y., Jacobs, William R., Freundlich, Joel S.

Journal:

Tetrahedron Letters

Year:

2015

Language:

english

File:

PDF, 645 KB

english, 2015

27

Bioorganic Chemistry: Peptides and Proteins Edited by Sidney M. Hecht. Oxford University Press, New York. 1998. x + 532 pp. 17 × 24.5 cm. ISBN 0-19-508468-3. $75.00.

Freundlich, Joel S., Olson, Gary L.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 25 KB

english, 1999

28

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads

Anantpadma, Manu, Lane, Thomas, Zorn, Kimberley M., Lingerfelt, Mary A., Clark, Alex M., Freundlich, Joel S., Davey, Robert A., Madrid, Peter B., Ekins, Sean

Journal:

Year:

2019

File:

PDF, 1.30 MB

2019

29

A brief review of recent Charcot-Marie-Tooth research and priorities

Ekins, Sean, Litterman, Nadia K., Arnold, Renée J.G., Burgess, Robert W., Freundlich, Joel S., Gray, Steven J., Higgins, Joseph J., Langley, Brett, Willis, Dianna E., Notterpek, Lucia, Pleasure, David

Journal:

Year:

2015

Language:

english

File:

PDF, 1.44 MB

english, 2015

30

Pruned Machine Learning Models to Predict Aqueous Solubility

Perryman, Alexander L., Inoyama, Daigo, Patel, Jimmy S., Ekins, Sean, Freundlich, Joel S.

Journal:

Year:

2020

File:

PDF, 1.57 MB

2020

31

In silico repositioning of approved drugs for rare and neglected diseases

Sean Ekins, Antony J. Williams, Matthew D. Krasowski, Joel S. Freundlich

Journal:

Drug Discovery Today

Year:

2011

Language:

english

File:

PDF, 686 KB

english, 2011

32

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

Lotesta, Stephen D., Liu, Junjia, Yates, Emma V., Krieger, Inna, Sacchettini, James C., Freundlich, Joel S., Sorensen, Erik J.

Journal:

Chemical Science

Year:

2011

Language:

english

File:

PDF, 187 KB

english, 2011

33

Morphological profiling of tubercle bacilli identifies drug pathways of action

Smith, Trever C., Pullen, Krista M., Olson, Michaela C., McNellis, Morgan E., Richardson, Ian, Hu, Sophia, Larkins-Ford, Jonah, Wang, Xin, Freundlich, Joel S., Ando, D. Michael, Aldridge, Bree B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 937 KB

2020

34

Inhibition of excessive scleroderma fibroblast collagen production by recombinant γ-interferon: Association with a coordinate decrease in types I and III procollagen messenger RNA levels

Joel Rosenbloom, George Feldman, Bruce Freundlich, Sergio A. Jimenez

Journal:

Arthritis & Rheumatism

Year:

1986

Language:

english

File:

PDF, 540 KB

english, 1986

35

Synthesis of Triamidoamine Complexes of Niobium

Freundlich, Joel S., Schrock, Richard R.

Journal:

Inorganic Chemistry

Year:

1996

Language:

english

File:

PDF, 92 KB

english, 1996

36

Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters

Vila-Farres, Xavier, Chu, John, Inoyama, Daigo, Ternei, Melinda A., Lemetre, Christophe, Cohen, Louis J., Cho, Wooyoung, Reddy, Boojala Vijay B., Zebroski, Henry A., Freundlich, Joel S., Perlin, David

Journal:

Journal of the American Chemical Society

Year:

2017

Language:

english

File:

PDF, 2.78 MB

english, 2017

37

Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery

Lane, Thomas, Russo, Daniel P, Zorn, Kimberley M, Clark, Alex Michael, Korotcov, Alexandru, Tkachenko, Valery, Reynolds, Robert C., Perryman, Alexander Luke, Freundlich, Joel Stephen, Ekins, Sean

Journal:

Molecular Pharmaceutics

Year:

2018

Language:

english

File:

PDF, 1.79 MB

english, 2018

38

Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae

Pereira, Janaina Cruz, Daher, Samer S., Zorn, Kimberley M., Sherwood, Matthew, Russo, Riccardo, Perryman, Alexander L., Wang, Xin, Freundlich, Madeleine J., Ekins, Sean, Freundlich, Joel S.

Journal:

Pharmaceutical Research

Year:

2020

File:

PDF, 613 KB

2020

39

Synthetic and Mechanistic Investigations of Trimethylsilyl-Substituted Triamidoamine Complexes of Tantalum That Contain Metal−Ligand Multiple Bonds

Freundlich, Joel S., Schrock, Richard R., Davis, William M.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 440 KB

english, 1996

40

Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis

Sacchettini, James C., Rubin, Eric J., Freundlich, Joel S.

Journal:

Nature Reviews Microbiology

Year:

2008

Language:

english

File:

PDF, 814 KB

english, 2008

41

Computational databases, pathway and cheminformatics tools for tuberculosis drug discovery

Sean Ekins, Joel S. Freundlich, Inhee Choi, Malabika Sarker, Carolyn Talcott

Journal:

Trends in Microbiology

Year:

2011

Language:

english

File:

PDF, 330 KB

english, 2011

42

SPIE Proceedings [SPIE Application of Optical Instrumentation in Medicine III - Kansas City (Thursday 1 August 1974)] Application of Optical Instrumentation in Medicine III - Psychophysics From A Radiologist's Point Of View

Capp, M. P., Gray, Joel, Seeley, George, Freundlich, Irwin M., Carson, Paul L., Chaney, Edward L., Hendee, William R.

Year:

1975

Language:

english

File:

PDF, 2.53 MB

english, 1975

43

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis

Forbes, Lauren, Ebsworth-Mojica, Katherine, DiDone, Louis, Li, Shao-Gang, Freundlich, Joel S., Connell, Nancy, Dunman, Paul M., Krysan, Damian J., Neyrolles, Olivier

Journal:

Year:

2015

Language:

english

File:

PDF, 2.25 MB

english, 2015

44

Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

Inna V. Krieger, Joel S. Freundlich, Vijay B. Gawandi, Justin P. Roberts, Vidyadhar B. Gawandi, Qingan Sun, Joshua L. Owen, Maria T. Fraile, Sofia I. Huss, Jose-Luis Lavandera, Thomas R. Ioerger, Jame

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 738 KB

english, 2012

45

Looking Back to the Future: Predicting in Vivo Efficacy of Small Molecules versus Mycobacterium tuberculosis

Ekins, Sean, Pottorf, Richard, Reynolds, Robert C., Williams, Antony J., Clark, Alex M., Freundlich, Joel S.

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 3.87 MB

english, 2014

46

Human microbiome inspired antibiotics with improved β-lactam synergy against MDR Staphylococcus aureus

Chu, John, Vila Farres, Xavier, Inoyama, Daigo, Gallardo-Macias, Ricardo, Jaskowski, Mark, Satish, Shruthi, Freundlich, Joel Stephen, Brady, Sean F.

Journal:

ACS Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 999 KB

english, 2017

47

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives

Joel S. Freundlich, Min Yu, Edinson Lucumi, Mack Kuo, Han-Chun Tsai, Juan-Carlos Valderramos, Luchezar Karagyozov, William R. Jacobs Jr., Guy A. Schiehser, David A. Fidock, David P. Jacobus, James C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 219 KB

english, 2006

48

An expeditious aqueous Suzuki–Miyaura method for the arylation of bromophenols

Joel S. Freundlich, Howard E. Landis

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

49

Validating New Tuberculosis Computational Models with Public Whole Cell Screening Aerobic Activity Datasets

Sean Ekins, Joel S. Freundlich

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 621 KB

english, 2011

50

Patient-Reported Outcomes and Health-Care Resource Utilization in Patients with Psoriasis Treated with Etanercept: Continuous versus Interrupted Treatment

Joel M. Gelfand, Alexa B. Kimball, Eliot N. Mostow, Chiun-Fang Chiou, Vaishali Patel, H. Amy Xia, Bruce Freundlich, Seth R. Stevens

Journal:

Value in Health

Year:

2008

Language:

english

File:

PDF, 289 KB

english, 2008

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